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Hippocampal TERT Regulates Spatial Memory Formation through Modulation of Neural Development

27 Jul 2017

Abstract excerpt

) causes extremely poor ability in spatial memory formation. Knockdown of TERT in the dentate gyrus of adult hippocampus impairs spatial memory processes, while overexpression facilitates it. We find that TERT plays a critical role in neural development including dendritic development and neuritogenesis of hippocampal newborn neurons. A monosynaptic pseudotyped rabies virus retrograde tracing method shows that...

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PMID: 28757168
DOI: 10.1016/j.stemcr.2017.06.014

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