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Article

Novel telomerase‐increasing compound in mouse brain delays the onset of amyotrophic lateral sclerosis

20 Feb 2012

Abstract excerpt

Telomerase is expressed in the neonatal brain, in distinct regions of adult brain, and was shown to protect developing neurons from apoptosis. Telomerase reactivation by gene manipulation reverses neurodegeneration in aged telomerase-deficient mice. Hence, we and others hypothesized that increasing telomerase expression by pharmaceutical compounds may protect brain cells from death caused by damaging agents. In...

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PMID: 22351600
DOI: 10.1002/emmm.201200212

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