Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tissue transglutaminase overexpression in the brain potentiates calcium-induced hippocampal damage.

Journal of neurochemistry - 1 Apr 2006

Tucholski Janusz, Roth Kevin A, Johnson Gail V W

Abstract excerpt

Tissue transglutaminase (tTG) post-translationally modifies proteins in a calcium-dependent manner by incorporation of polyamines, deamination or crosslinking. Moreover, tTG can also bind and hydrolyze GTP. tTG is the major transglutaminase in the mammalian nervous system, localizing predominantl...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Excitatory Amino Acid Agonists
Share to Guanosine Triphosphate
Share to In Situ Nick-End Labeling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kainic Acid

Share to Phosphopyruvate Hydratase

Share to Seizures

Share to Staining and Labeling

Share to Transglutaminases

Source

Identifiers

PMID: 16539654
DOI: 10.1111/j.1471-4159.2006.03780.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16539654-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tissue transglutaminase overexpression in the brain potentiates calcium-induced hippocampal damage.PMID 16539654Read ↗

Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation.Semantic proximity Read ↗

Increased susceptibility of glutathione peroxidase-1 transgenic mice to kainic acid-related seizure activity and hippocampal neuronal cell death.Semantic proximity Read ↗

‘Tissue’ transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's diseaseSemantic proximity Read ↗

Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in TauopathySemantic proximity Read ↗

Overexpression of Telomerase Reverse Transcriptase Induces Autism-like Excitatory Phenotypes in Mice.Semantic proximity Read ↗

Type 2 transglutaminase differentially modulates striatal cell death in the presence of wild type or mutant huntingtin.Semantic proximity Read ↗

Chronic low-level expression of HIV-1 Tat promotes a neurodegenerative phenotype with aging.Semantic proximity Read ↗

Overexpression of gamma-aminobutyric acid transporter subtype I leads to susceptibility to kainic acid-induced seizure in transgenic mice.Semantic proximity Read ↗

Trimethyltin Increases Intracellular Ca2+ Via L-Type Voltage-Gated Calcium Channels and Promotes Inflammatory Phenotype in Rat Astrocytes In Vitro.Semantic proximity Read ↗

Impaired Glutamate Transport in a Mouse Model of Tau Pathology in AstrocytesSemantic proximity Read ↗

Intracellular localization and conformational state of transglutaminase 2: implications for cell death.Semantic proximity Read ↗

Transgenic Mouse Model of Tau Pathology in Astrocytes Leading to Nervous System DegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.