Article
Association of Vascular Risk Factors and Genetic Factors With Penetrance of Variants Causing Monogenic Stroke
27 Oct 2022
Abstract excerpt
Importance: It is uncertain whether typical variants causing monogenic stroke are associated with cerebrovascular disease in the general population and why the phenotype of these variants varies so widely. Objective: To determine the frequency of pathogenic variants in the 3 most common monogenic cerebral small vessel diseases (cSVD) and their associations with prevalent and incident stroke and dementia. Design,...