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Article

Cardiovascular health, genetic susceptibility, and the risk of ischemic stroke: A large prospective cohort study.

International journal of cardiology - 15 Jun 2026

Huang Yuezhong, Ruan Miaohua, Zhang Hao, Shen Yifan, Zhou Mi, Song Hongzi, Lu Fan, Gao Hebei, Chu Maoping, Xu Longlong

Abstract excerpt

BACKGROUND: Ischemic stroke (IS) remains a major cause of death and disability. We assessed the association between cardiovascular health (CVH), quantified by Life's Essential 8 (LE8), and incident IS, and examined whether polygenic risk score (PRS) modifies this association. METHODS: We studied 234,991 UK Biobank participants with no history of ischemic stroke at baseline (median age 58 years [IQR, 50-64];...

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PMID: 41850600
DOI: 10.1016/j.ijcard.2026.134292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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