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Polygenic risk scores improve stroke risk stratification in Chinese adults: Validation from the Chinese multi-provincial cohort study.

International journal of stroke : official journal of the International Stroke Society - 1 Jul 2026

Wang Zongwei, Jia Pingping, Zhou Pan, Qi Yue, Sun Jiayi, Liu Jun, Wang Miao, Deng Qiuju, Hao Yongchen, Yang Na, Han Lizhen, Liu Jing, Du Jie, Yang Zhao

Abstract excerpt

OBJECTIVE: To validate whether incorporating existing polygenic risk scores (PRSs) derived from East Asian or trans-ancestry populations into clinical risk equations improves stroke risk stratification in Chinese adults. METHODS: Participants from the Chinese Multi-provincial Cohort study with genotyped data (n = 2931) were included. Four well-established PRSs (i.e., PRS-GBMI, PRS-GIGA, PRS-ChinaPAR, and...

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PMID: 41175054
DOI: 10.1177/17474930251396062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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