Article
Germline RECQL mutations in high risk Chinese breast cancer patients.
Breast cancer research and treatment - 1 Jun 2016
Kwong Ava, Shin Vivian Y, Cheuk Isabella W Y, Chen Jiawei, Au Chun H, Ho Dona N, Chan Tsun L, Ma Edmond S K, Akbari Mohammad R, Narod Steven A
Abstract excerpt
Recently, RECQL was reported as a new breast cancer susceptibility gene. RECQL belongs to the RECQ DNA helicase family which unwinds double strand DNA and involved in the DNA replication stress response, telomere maintenance and DNA repair. RECQL deficient mice cells are prone to spontaneous chromosomal instability and aneuploidy, suggesting a tumor-suppressive role of RECQL in cancer. In this study, RECQL gene...
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