Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Notch Signaling Regulates Bile Duct Morphogenesis in Mice

25 Mar 2008

Abstract excerpt

BACKGROUND: Alagille syndrome is a developmental disorder caused predominantly by mutations in the Jagged1 (JAG1) gene, which encodes a ligand for Notch family receptors. A characteristic feature of Alagille syndrome is intrahepatic bile duct paucity. We described previously that mice doubly heterozygous for Jag1 and Notch2 mutations are an excellent model for Alagille syndrome. However, our previous study did...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Liver physiology and pathology
Share to Pediatric Hepatobiliary Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18365007
DOI: 10.1371/journal.pone.0001851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Notch Signaling Regulates Bile Duct Morphogenesis in MicePMID 18365007Read ↗

Bile duct proliferation in Jag1/fringe heterozygous mice identifies candidate modifiers of the Alagille syndrome hepatic phenotype.Semantic proximity Read ↗

A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency.Semantic proximity Read ↗

Liver‐specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice†‡Semantic proximity Read ↗

Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome.Semantic proximity Read ↗

Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopySemantic proximity Read ↗

Endoderm Jagged induces liver and pancreas duct lineage in zebrafishSemantic proximity Read ↗

Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations.Semantic proximity Read ↗

Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage.Semantic proximity Read ↗

Notch signaling controls liver development by regulating biliary differentiationSemantic proximity Read ↗

Regenerative failure of intrahepatic biliary cells in Alagille syndrome rescued by elevated Jagged/Notch/Sox9 signalingSemantic proximity Read ↗

Alagille syndrome and the Jagged1 gene.Semantic proximity Read ↗

The role of Notch receptor expression in bile duct development and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.