Article
Mutation-Independent Activation of the Anaplastic Lymphoma Kinase in Neuroblastoma.
The American journal of pathology - 1 Feb 2016
Regairaz Marie, Munier Fabienne, Sartelet Hervé, Castaing Marine, Marty Virginie, Renauleaud Céline, Doux Camille, Delbé Jean, Courty José, Fabre Monique, Ohta Shigeru, Vielh Philippe, Michiels Stefan, Valteau-Couanet Dominique, Vassal Gilles
Abstract excerpt
Activating mutations of anaplastic lymphoma kinase (ALK) have been identified as important players in neuroblastoma development. Our goal was to evaluate the significance of overall ALK activation in neuroblastoma. Expression of phosphorylated ALK, ALK, and its putative ligands, pleiotrophin and midkine, was screened in 289 neuroblastomas and 56 paired normal tissues. ALK was expressed in 99% of tumors and...
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