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Development of anaplastic lymphoma kinase (ALK) small‐molecule inhibitors for cancer therapy

10 Aug 2007

Abstract excerpt

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) involved in the genesis of several human cancers; indeed, ALK was initially identified in constitutively activated and oncogenic fusion forms--the most common being nucleophosmin (NPM)-ALK--in a non-Hodgkin's lymphoma (NHL) known as anaplastic large-cell lymphoma (ALCL) and subsequent studies identified ALK fusions in the human sarcomas called...

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PMID: 17694547
DOI: 10.1002/med.20109

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