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Screening for germline mutations in breast/ovarian cancer susceptibility genes in high-risk families in Israel.

Breast cancer research and treatment - 1 Jan 2016

Yablonski-Peretz Tamar, Paluch-Shimon Shani, Gutman Lior Soussan, Kaplan Yulia, Dvir Addie, Barnes-Kedar Inbal, Kadouri Luna, Semenisty Valeriya, Efrat Noa, Neiman Victoria, Glasser Yafit, Michaelson-Cohen Rachel, Katz Lior, Kaufman Bella, Golan Talia, Reish Orit, Hubert Ayala, Safra Tamar, Yaron Yuval, Friedman Eitan

Abstract excerpt

We evaluated the clinical utility of screening for mutations in 34 breast/ovarian cancer susceptibility genes in high-risk families in Israel. Participants were recruited from 12, 2012 to 6, 2015 from 8 medical centers. All participants had high breast/ovarian cancer risk based on personal and family history. Genotyping was performed with the InVitae™ platform. The study was approved by the ethics committees of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26687385
DOI: 10.1007/s10549-015-3662-2

Genes

BRCA1
APC
BRCA2
CHEK2
MSH2
MSH6
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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