Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 May 2016

Tung Nadine, Lin Nancy U, Kidd John, Allen Brian A, Singh Nanda, Wenstrup Richard J, Hartman Anne-Renee, Winer Eric P, Garber Judy E

Abstract excerpt

PURPOSE: Testing for germline mutations in BRCA1/2 is standard for select patients with breast cancer to guide clinical management. Next-generation sequencing (NGS) allows testing for mutations in additional breast cancer predisposition genes. The frequency of germline mutations detected by using NGS has been reported in patients with breast cancer who were referred for BRCA1/2 testing or with triple-negative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, BRCA1
Share to Genes, BRCA2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to Neoplasm Staging

Share to Ovarian Neoplasms

Share to Predictive Value of Tests

Share to Triple Negative Breast Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 26976419
DOI: 10.1200/JCO.2015.65.0747
PMCID: PMC4872307

Genes

BRCA1
ATM
BRIP1
CHEK2
MSH6
NBN
PALB2
PMS2
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer.PMID 26976419Read ↗

Frequency of mutations in individuals with breast cancer referred for BRCA1 and BRCA2 testing using next-generation sequencing with a 25-gene panel.Semantic proximity Read ↗

Detection of Germline Mutations in Patients with Epithelial Ovarian Cancer Using Multi-gene Panels: Beyond BRCA1/2Semantic proximity Read ↗

Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: analysis of 10,000 individuals.Semantic proximity Read ↗

Detection of Germline Mutations in Breast Cancer Patients with Clinical Features of Hereditary Cancer Syndrome Using a Multi-Gene Panel Test.Semantic proximity Read ↗

Evaluation of Germline Genetic Testing Criteria in a Hospital-Based Series of Women With Breast Cancer.Semantic proximity Read ↗

Prevalence of mutations in a panel of breast cancer susceptibility genes in BRCA1/2-negative patients with early-onset breast cancer.Semantic proximity Read ↗

Inherited predisposition to breast and ovarian cancer in non-Jewish populations in Israel.Semantic proximity Read ↗

Genetic Predisposition to Breast Cancer Due to Mutations Other Than BRCA1 and BRCA2 Founder Alleles Among Ashkenazi Jewish Women.Semantic proximity Read ↗

Multi-Gene Mutation Profiling by Targeted Next-Generation Sequencing in Premenopausal Breast Cancer.Semantic proximity Read ↗

Contribution of germline mutations in cancer predisposition genes to tumor etiology in young women diagnosed with invasive breast cancer.Semantic proximity Read ↗

Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer.Semantic proximity Read ↗

Hereditary predisposition to ovarian cancer, looking beyond BRCA1/BRCA2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.