Article
The yield of targeted genotyping for the recurring mutations in BRCA1/2 in Israel.
Breast cancer research and treatment - 1 Feb 2018
Bernstein-Molho Rinat, Laitman Yael, Schayek Hagit, Reish Orit, Lotan Shira, Haim Sara, Zidan Jamal, Friedman Eitan
Abstract excerpt
BACKGROUND: Hereditary breast cancer is predominantly associated with germline mutations in the BRCA1 or BRCA2 genes. A few recurring mutations in these genes were reported in ethnically diverse Jewish populations. Since 2013, most oncogenetic laboratories in Israel adopted a two-step approach for BRCA1/2 genotyping, where the first step is genotyping for 14 seemingly recurring mutations-first-pass genotyping....
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