Multigene panels in Ashkenazi Jewish patients yield high rates of actionable mutations in multiple non-BRCA cancer-associated genes.

doi:10.1016/j.ygyno.2017.04.009

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Article

Multigene panels in Ashkenazi Jewish patients yield high rates of actionable mutations in multiple non-BRCA cancer-associated genes.

Gynecologic oncology - 1 Jul 2017

Frey Melissa K, Sandler Gabriella, Sobolev Rachel, Kim Sarah H, Chambers Rachelle, Bassett Rebecca Y, Martineau Jessica, Sapra Katherine J, Boyd Leslie, Curtin John P, Pothuri Bhavana, Blank Stephanie V

Abstract excerpt

OBJECTIVE: To evaluate the results of multigene panel testing among Ashkenazi Jewish compared with non-Ashkenazi Jewish patients. METHODS: We reviewed the medical records for all patients who underwent multigene panel testing and targeted BRCA1/2 testing at a single institution between 6/2013-1/2015. Clinical actionability for identified pathogenic mutations was characterized based on the National Comprehensive...

Topics

Adult
Aged
Aged, 80 and over
Family Health
Female
Genes, BRCA1
Genes, BRCA2
Genetic Predisposition to Disease
Genetic Testing
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Jews

Male

Middle Aged

Multigene Family

Mutation

Neoplasms

Source

Open in PubMed

Identifiers

PMID: 28495237
DOI: 10.1016/j.ygyno.2017.04.009

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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