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Outcomes of multigene panel testing for hereditary cancer in two Israeli medical centers 2013-2024.

Cancer genetics - 1 Jun 2026

Laitman Yael, Zalmanoviz Shelley, Netzer Iris, Bernstein-Molho Rinat, Friedman Eitan

Abstract excerpt

PURPOSE: Multigene panel testing (MGPT) enables simultaneous detection of germline pathogenic/likely pathogenic variants (P/LP SV) in cancer susceptibility genes (CSG). The utility of MGPT in Israel, where most individuals eligible for oncogenetic testing undergo first-pass genotyping for predominant PSVs in the BRCA1, BRCA2, MSH2, and MSH6 genes, has not been reported. METHODS: Individuals who underwent MGPT...

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Source

Identifiers

PMID: 41819754
DOI: 10.1016/j.cancergen.2026.03.002

Genes

BRCA1
BRCA2
CHEK2
MSH2
MSH6
ATM
CDKN2A
PMS2

Variants

Provenance

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