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The patterns and spectrum of BRCA1 and BRCA2 mutations in Iranian breast and ovarian cancer patients.

Familial cancer - 30 Mar 2025

Forghani Shayan, Mirzaee Hamid Reza, Rezvani Hamid, Forghani Arman, Mahdavi Sabet Fatemeh, Hojjat Ali, Malekzadeh Mona, Akbari Atieh, Tabarestani Sanaz

Abstract excerpt

Women with inherited BRCA1/2 mutations are at increased risk of breast and ovarian cancer. The reports on the prevalence and spectrum of these mutations have been primarily focused on individuals with European ancestry. A previous study on Iranian breast cancer patients reported no BRCA1/2 mutation in early-onset breast cancer with no other criteria, which is contrary to other populations. The purpose of this...

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Identifiers

PMID: 40159529
DOI: 10.1007/s10689-025-00459-7

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BRCA1
BRCA2

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