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The patterns and spectrum of BRCA1 and BRCA2 mutations in Iranian breast and ovarian cancer patients.

Familial cancer - 30 Mar 2025

Forghani Shayan, Mirzaee Hamid Reza, Rezvani Hamid, Forghani Arman, Mahdavi Sabet Fatemeh, Hojjat Ali, Malekzadeh Mona, Akbari Atieh, Tabarestani Sanaz

Abstract excerpt

Women with inherited BRCA1/2 mutations are at increased risk of breast and ovarian cancer. The reports on the prevalence and spectrum of these mutations have been primarily focused on individuals with European ancestry. A previous study on Iranian breast cancer patients reported no BRCA1/2 mutation in early-onset breast cancer with no other criteria, which is contrary to other populations. The purpose of this...

Topics

Humans
Female
Iran
Middle Aged
Adult
BRCA2 Protein
BRCA1 Protein
Ovarian Neoplasms
Retrospective Studies
Breast Neoplasms
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Aged

Mutation

Genetic Testing

Source

Identifiers

PMID: 40159529
DOI: 10.1007/s10689-025-00459-7

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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