Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neutralizing Monoclonal Antibodies Block Chikungunya Virus Entry and Release by Targeting an Epitope Critical to Viral Pathogenesis.

Cell reports - 22 Dec 2015

Jin Jing, Liss Nathan M, Chen Dong-Hua, Liao Maofu, Fox Julie M, Shimak Raeann M, Fong Rachel H, Chafets Daniel, Bakkour Sonia, Keating Sheila, Fomin Marina E, Muench Marcus O, Sherman Michael B, Doranz Benjamin J, Diamond Michael S, Simmons Graham

Abstract excerpt

We evaluated the mechanism by which neutralizing human monoclonal antibodies inhibit chikungunya virus (CHIKV) infection. Potently neutralizing antibodies (NAbs) blocked infection at multiple steps of the virus life cycle, including entry and release. Cryo-electron microscopy structures of Fab fragments of two human NAbs and chikungunya virus-like particles showed a binding footprint that spanned independent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to Arthritis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokines

Share to Chikungunya virus

Share to Epitope Mapping

Share to Membrane Fusion

Share to Vero Cells

Share to Virus Internalization

Source

Open in PubMed Open full text

Identifiers

PMID: 26686638
DOI: 10.1016/j.celrep.2015.11.043
PMCID: PMC4720387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neutralizing Monoclonal Antibodies Block Chikungunya Virus Entry and Release by Targeting an Epitope Critical to Viral Pathogenesis.PMID 26686638Read ↗

Structural Studies of Chikungunya Virus-Like Particles Complexed with Human Antibodies: Neutralization and Cell-to-Cell TransmissionSemantic proximity Read ↗

Chikungunya virus neutralization antigens and direct cell-to-cell transmission are revealed by human antibody-escape mutants.Semantic proximity Read ↗

Deep mutationally scanned (DMS) CHIKV E3/E2 virus library maps viral amino acid preferences and predicts viral escape mutants of neutralizing CHIKV antibodiesSemantic proximity Read ↗

Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralizationSemantic proximity Read ↗

Exposure of Epitope Residues on the Outer Face of the Chikungunya Virus Envelope Trimer Determines Antibody Neutralizing EfficacySemantic proximity Read ↗

Deep mutationally scanned CHIKV E3/E2 virus library maps viral amino acid preferences and predicts viral escape mutants of neutralizing CHIKV antibodies.Semantic proximity Read ↗

Evolution of antiviral resistance captures a transient interdomain functional interaction between chikungunya virus envelope glycoproteins.Semantic proximity Read ↗

A Specific Domain of the Chikungunya Virus E2 Protein Regulates Particle Formation in Human Cells: Implications for Alphavirus Vaccine DesignSemantic proximity Read ↗

An Alphavirus E2 Membrane-Proximal Domain Promotes Envelope Protein Lateral Interactions and Virus Budding.Semantic proximity Read ↗

Evolution and immunopathology of chikungunya virus informs therapeutic development.Semantic proximity Read ↗

Chikungunya virus host range E2 transmembrane deletion mutants induce protective immunity against challenge in C57BL/6J mice.Semantic proximity Read ↗

Changes in the chikungunya virus E1 glycoprotein domain II and hinge influence E2 conformation, infectivity, and virus-receptor interactions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.