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Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization

2 Apr 2013

Abstract excerpt

A 5.3 Å resolution, cryo-electron microscopy (cryoEM) map of Chikungunya virus-like particles (VLPs) has been interpreted using the previously published crystal structure of the Chikungunya E1-E2 glycoprotein heterodimer. The heterodimer structure was divided into domains to obtain a good fit to the cryoEM density. Differences in the T = 4 quasi-equivalent heterodimer components show their adaptation to different...

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PMID: 23577234
DOI: 10.7554/elife.00435

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