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Article

Chikungunya virus host range E2 transmembrane deletion mutants induce protective immunity against challenge in C57BL/6J mice.

Journal of virology - 1 Jun 2013

Piper Amanda, Ribeiro Mariana, Smith Katherine M, Briggs Caitlin M, Huitt Emerson, Nanda Kavita, Spears Carla J, Quiles Michelle, Cullen John, Thomas Malcolm E, Brown Dennis T, Hernandez Raquel

Abstract excerpt

A vaccine against Chikungunya virus (ChikV), a reemerging pathogenic arbovirus, has been made by attenuating wild-type (WT) virus via truncation of the transmembrane domain (TMD) of E2 and selecting for host range (HR) mutants. Mice are a standard model system for ChikV disease and display the same symptoms of the disease seen in humans. Groups of mice were inoculated with one of three ChikV HR mutants to...

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Identifiers

PMID: 23552427
DOI: 10.1128/JVI.03357-12
PMCID: PMC3676113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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