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Article

Whole-exome tumor sequencing study in biliary cancer patients with a response to MEK inhibitors.

Oncotarget - 2 Feb 2016

Ahn Daniel H, Ozer Hatice Gulcin, Hancioglu Baris, Lesinski Gregory B, Timmers Cynthia, Bekaii-Saab Tanios

Abstract excerpt

We previously conducted a phase-II study with selumetinib (AZD6244), a small molecule inhibitor of MEK1/2, in advanced biliary tract cancers (BTC), where the primary endpoint was response rate. Several patients experienced objective response. These findings were confirmed with MEK162 in a similar patient population. To assess for tumor-specific genetic variants that mediate sensitivity to MEK inhibition in BTC,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26683364
DOI: 10.18632/oncotarget.6632
PMCID: PMC4868687

Genes

BTC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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