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Article

KRAS Allelic Variants in Biliary Tract Cancers.

JAMA network open - 1 May 2024

Moffat Gordon Taylor, Hu Zishuo Ian, Meric-Bernstam Funda, Kong Elisabeth Kathleen, Pavlick Dean, Ross Jeffrey S, Murugesan Karthikeyan, Kwong Lawrence, De Armas Anaemy Danner, Korkut Anil, Javle Milind, Knox Jennifer J

Abstract excerpt

Importance: Biliary tract cancers (BTCs) contain several actionable molecular alterations, including FGFR2, IDH1, ERBB2 (formerly HER2), and KRAS. KRAS allelic variants are found in 20% to 30% of BTCs, and multiple KRAS inhibitors are currently under clinical investigation. Objectives: To describe the genomic landscape, co-sequence variations, immunophenotype, genomic ancestry, and survival outcomes of...

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Identifiers

PMID: 38709532
DOI: 10.1001/jamanetworkopen.2024.9840
PMCID: PMC11074811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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