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Article

Molecular and Clinical Determinants of Targeted Therapy Treatment in Biliary Tract Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2026

Cowzer Darren, Walch Henry, Atri Pranita, Shah Farheen, Huq Risha, Thummalapalli Rohit, Nagib Fatema, Varghese Anna, Khalil Danny N, Park Wungki, Rousseau Benoit, Cercek Andrea, Erinjeri Joseph, Yeh Randy, Do Richard K, Basturk Olca, Shia Jinru, Chakravarty Debyani, Berger Michael F, Schultz Nikolaus, Gonen Mithat, O'Reilly Eileen M, Jarnagin William, Abou-Alfa Ghassan K, Solit David B, Chatila Walid K, Harding James J

Abstract excerpt

PURPOSE: Actionable genomic alterations occur in all anatomic subsets of biliary tract cancer; however, targeted therapies have not shown a survival advantage over cytotoxics, and resistance mechanisms require further characterization. EXPERIMENTAL DESIGN: We analyzed a prospectively maintained cohort of 1,254 patients with histologically confirmed biliary tract cancer who underwent molecular profiling using an...

Read the complete abstract on PubMed

Topics

Humans
Biliary Tract Neoplasms
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Molecular Targeted Therapy

Middle Aged

Aged

Biomarkers, Tumor

High-Throughput Nucleotide Sequencing

Mutation

Adult

Drug Resistance, Neoplasm

Aged, 80 and over

Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 42360806
DOI: 10.1158/1078-0432.CCR-26-0428
PMCID: PMC13420548

Genes

ERBB2
MET
BRAF
CDKN2A
FGFR2
IDH1
KRAS
MDM2
MTAP
MYC
SMAD4
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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