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Article

Angiotensinogen Exerts Effects Independent of Angiotensin II.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2016

Lu Hong, Wu Congqing, Howatt Deborah A, Balakrishnan Anju, Moorleghen Jessica J, Chen Xiaofeng, Zhao Mingming, Graham Mark J, Mullick Adam E, Crooke Rosanne M, Feldman David L, Cassis Lisa A, Vander Kooi Craig W, Daugherty Alan

Abstract excerpt

OBJECTIVE: This study determined whether angiotensinogen (AGT) has angiotensin II-independent effects using multiple genetic and pharmacological manipulations. APPROACH AND RESULTS: All study mice were in low-density lipoprotein receptor -/- background and fed a saturated fat-enriched diet. In mice with floxed alleles and a neomycin cassette in intron 2 of the AGT gene (hypoAGT mice), plasma AGT concentrations...

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Identifiers

PMID: 26681751
DOI: 10.1161/ATVBAHA.115.306740
PMCID: PMC4732917

Genes

AGT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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