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Article

Antisense oligonucleotides targeting angiotensinogen: insights from animal studies

10 Dec 2018

Abstract excerpt

Angiotensinogen (AGT) is the unique substrate of all angiotensin peptides. We review the recent preclinical research of AGT antisense oligonucleotides (ASOs), a rapidly evolving therapeutic approach. The scope of the research findings not only opens doors for potentially new therapeutics of hypertension and many other diseases, but also provides insights into understanding critical physiological and...

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PMID: 30530571
DOI: 10.1042/bsr20180201

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