Article
Increased prevalence of lung, breast, and pancreatic cancers in addition to melanoma risk in families bearing the cyclin-dependent kinase inhibitor 2A mutation: implications for genetic counseling.
Journal of the American Academy of Dermatology - 1 Nov 2014
Potrony Miriam, Puig-Butillé Joan Anton, Aguilera Paula, Badenas Celia, Carrera Cristina, Malvehy Josep, Puig Susana
Abstract excerpt
BACKGROUND: Cyclin-dependent kinase inhibitor 2A (CDKN2A) is the major high-risk susceptibility gene for melanoma. OBJECTIVE: We sought to evaluate the effect of CDKN2A mutations in Spanish patients with a high risk of developing melanoma and the association with clinical and family history features. METHODS: A cross-sectional study design was used to analyze the CDKN2A impact in 702 Spanish patients with a high...
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