Article
Molecular characterization of melanoma cases in Denmark suspected of genetic predisposition.
PloS one - 1 Jan 2015
Wadt Karin A W, Aoude Lauren G, Krogh Lotte, Sunde Lone, Bojesen Anders, Grønskov Karen, Wartacz Nine, Ek Jakob, Tolstrup-Andersen Morten, Klarskov-Andersen Mette, Borg Åke, Heegaard Steffen, Kiilgaard Jens F, Hansen Thomas V O, Klein Kerenaftali, Jönsson Göran, Drzewiecki Krzysztof T, Dunø Morten, Hayward Nicholas K, Gerdes Anne-Marie
Abstract excerpt
Both environmental and host factors influence risk of cutaneous melanoma (CM), and worldwide, the incidence varies depending on constitutional determinants of skin type and pigmentation, latitude, and patterns of sun exposure. We performed genetic analysis of CDKN2A, CDK4, BAP1, MC1R, and MITFp.E318K in Danish high-risk melanoma cases and found CDKN2A germline mutations in 11.3% of CM families with three or more...
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