Article
Metabolic and hormonal consequencies of the "obesity risk" MC4R variant (rs12970134) in Czech women.
Physiological research - 1 Jan 2015
Bradnová O, Vejražková D, Vaňková M, Lukášová P, Včelák J, Stanická S, Dvořáková K, Bendlová B
Abstract excerpt
Although the mutations in MC4R gene became known as the most common genetic cause of human obesity, the effect of rs12970134 A/G near MC4R gene on insulin resistance has been described. The aim of this study was to determine the effect of rs12970134 on obesity, hormone levels, and glucose metabolism in a cohort of women varying in glucose tolerance: 850 normoglycemic women, 423 diagnosed with polycystic ovary...
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