Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Common genetic variation near MC4R is associated with waist circumference and insulin resistance.

Nature genetics - 1 Jun 2008

Chambers John C, Elliott Paul, Zabaneh Delilah, Zhang Weihua, Li Yun, Froguel Philippe, Balding David, Scott James, Kooner Jaspal S

Abstract excerpt

We carried out a genome-wide association study (318,237 SNPs) for insulin resistance and related phenotypes in 2,684 Indian Asians, with further testing in 11,955 individuals of Indian Asian or European ancestry. We found associations of rs12970134 near MC4R with waist circumference (P = 1.7 x 10(-9)) and, independently, with insulin resistance. Homozygotes for the risk allele of rs12970134 have approximately 2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adiposity
Share to Body Mass Index
Share to Genetic Linkage
Share to Genome, Human
Share to Insulin Resistance
Share to Receptor, Melanocortin, Type 4
Share to Waist-Hip Ratio
Share to White People

Source

Identifiers

PMID: 18454146
DOI: 10.1038/ng.156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common genetic variation near MC4R is associated with waist circumference and insulin resistance.PMID 18454146Read ↗

Strong influence of variants near MC4R on adiposity in children and adults: a cross-sectional study in Indian population.Semantic proximity Read ↗

Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children.Semantic proximity Read ↗

Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian Sikhs.Semantic proximity Read ↗

Associations between a common variant near the MC4R gene and serum triglyceride levels in an obese pediatric cohort.Semantic proximity Read ↗

The genetic epidemiology of melanocortin 4 receptor variants.Semantic proximity Read ↗

Association of MC4R (rs17782313) gene polymorphism with obesity measures in Western India.Semantic proximity Read ↗

Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure.Semantic proximity Read ↗

Common variants near MC4R are associated with fat mass, weight and risk of obesity.Semantic proximity Read ↗

Association between common polymorphism near the MC4R gene and obesity risk: a systematic review and meta-analysis.Semantic proximity Read ↗

Common polymorphism near the MC4R gene is associated with type 2 diabetes: data from a meta-analysis of 123,373 individuals.Semantic proximity Read ↗

Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions.Semantic proximity Read ↗

Diverse effect of MC4R risk alleles on obesity-related traits over a lifetime: Evidence from a well-designed cohort study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.