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Article

Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein.

The Journal of biological chemistry - 24 Jan 2003

Herms Jochen, Schneider Ilka, Dewachter Ilse, Caluwaerts Nathalie, Kretzschmar Hans, Van Leuven Fred

Abstract excerpt

Mutant presenilin-1 (PS1) increases amyloid peptide production, attenuates capacitative calcium entry (CCE), and augments calcium release from the endoplasmatic reticulum (ER). Here we measured the intracellular free Ca(2+) concentration in hippocampal neurons from six different combinations of transgenic and gene-ablated mice to demonstrate that mutant PS1 attenuated CCE directly, independent of the expression...

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PMID: 12431992
DOI: 10.1074/jbc.M206769200

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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