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Article

Presenilin-1 Delta E9 Mutant Induces STIM1-Driven Store-Operated Calcium Channel Hyperactivation in Hippocampal Neurons.

Molecular neurobiology - 1 Jun 2018

Ryazantseva Maria, Goncharova Anna, Skobeleva Kseniia, Erokhin Maksim, Methner Axel, Georgiev Pavel, Kaznacheyeva Elena

Abstract excerpt

Presenilins regulate calcium homeostasis in the endoplasmic reticulum, and dysregulation of intracellular calcium has been implicated in the pathogenesis of Alzheimer disease. Elevated presenilin-1 (PS1) holoprotein levels have been detected in postmortem brains of patients carrying familial Alzheimer disease (FAD) PS1 mutations. This study examines the effect of the FAD presenilin mutant that lacks the ninth...

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Source

Identifiers

PMID: 28707074
DOI: 10.1007/s12035-017-0674-4

Genes

STIM1
STIM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Presenilin-1 Delta E9 Mutant Induces STIM1-Driven Store-Operated Calcium Channel Hyperactivation in Hippocampal Neurons.PMID 28707074Read ↗

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