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Article

Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis.

Science China. Life sciences - 1 Aug 2011

Supnet Charlene, Bezprozvanny Ilya

Abstract excerpt

Alzheimer disease (AD) is the most common neurodegenerative disorder worldwide and is at present, incurable. The accumulation of toxic amyloid-beta (Aβ) peptide aggregates in AD brain is thought to trigger the extensive synaptic loss and neurodegeneration linked to cognitive decline, an idea that underlies the 'amyloid hypothesis' of AD etiology in both the familal (FAD) and sporadic forms of the disease. Genetic...

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Identifiers

PMID: 21786197
DOI: 10.1007/s11427-011-4201-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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