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Article

Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity.

Biochemical and biophysical research communications - 1 Oct 2004

Akbari Yama, Hitt Brian D, Murphy M Paul, Dagher Nabil N, Tseng Bertrand P, Green Kim N, Golde Todd E, LaFerla Frank M

Abstract excerpt

Mutations in presenilin-1 and 2 (PS) lead to increased intracellular calcium stores and an attenuation in the refilling mechanism known as capacitative calcium entry (CCE). Previous studies have shown that the mechanism by which PS modulates intracellular calcium signaling is dependent on gamma-secretase activity. Although the modulation of intracellular calcium signaling can lead to alterations in CCE, it is...

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Identifiers

PMID: 15336962
DOI: 10.1016/j.bbrc.2004.07.136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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