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Article

Spontaneous ATM Gene Reversion in A-T iPSC to Produce an Isogenic Cell Line.

Stem cell reports - 8 Dec 2015

Lin Lucy, Swerdel Mavis R, Lazaropoulos Michael P, Hoffman Gary S, Toro-Ramos Alana J, Wright Jennifer, Lederman Howard, Chen Jianmin, Moore Jennifer C, Hart Ronald P

Abstract excerpt

A spontaneously reverted iPSC line was identified from an A-T subject with heterozygous ATM truncation mutations. The reverted iPSC line expressed ATM protein and was capable of radiation-induced phosphorylation of CHK2 and H2A.X. Genome-wide SNP analysis confirmed a match to source T cells and also to a distinct, non-reverted iPSC line from the same subject. Rearranged T cell receptor sequences predict that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26677768
DOI: 10.1016/j.stemcr.2015.10.010
PMCID: PMC4682125

Genes

ATM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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