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Article

Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells.

Scientific reports - 20 Jul 2017

Royba Ekaterina, Miyamoto Tatsuo, Natsuko Akutsu Silvia, Hosoba Kosuke, Tauchi Hiroshi, Kudo Yoshiki, Tashiro Satoshi, Yamamoto Takashi, Matsuura Shinya

Abstract excerpt

Ionizing radiation (IR) induces DNA double-strand breaks (DSBs), which are an initial step towards chromosomal aberrations and cell death. It has been suggested that there are individual differences in radiosensitivity within human populations, and that the variations in DNA repair genes might determine this heterogeneity. However, it is difficult to quantify the effect of genetic variants on the individual...

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Identifiers

PMID: 28729543
DOI: 10.1038/s41598-017-06393-8
PMCID: PMC5519549

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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