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Article

Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor.

Cancer research - 15 Apr 2003

Vu Thanh H, Chuyen Nguyen V, Li Tao, Hoffman Andrew R

Abstract excerpt

Human insulin-like growth factor II gene (IGF2) is overexpressed, and its imprinting is disrupted in many tumors, including Wilms' tumor. A transcript that is antisense to IGF2, IGF2-antisense (IGF2-AS), is transcribed from within IGF2 in a reverse orientation. This transcript is also maternally imprinted and overexpressed in Wilms' tumor. IGF2-AS was detected as a 2.2 kb mRNA in Hep 3B cells by Northern...

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Share to Genomic Imprinting
Share to Insulin-Like Growth Factor II
Share to Kidney Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to RNA, Antisense

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Source

Identifiers

PMID: 12702581

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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