Article
Monoallelic expression of the insulin-like growth factor-2 gene in ovarian cancer.
The American journal of pathology - 1 Apr 1996
Yun K, Fukumoto M, Jinno Y
Abstract excerpt
Genomic imprinting is defined as a gamete-specific modification causing differential expression of the two alleles of a gene in somatic cells and is becoming increasingly recognized as playing an important role in a number of human diseases including cancer. We have reported that the loss of the insulin-like growth factor-2 (IGF2) gene imprinting results in the deregulation of both IGF2 alleles, which may...
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