Article
Genetic variants in GAPDH confer susceptibility to sporadic Parkinson's disease in a Chinese Han population.
PloS one - 1 Jan 2015
Liu Ling, Xiong Nian, Zhang Ping, Chen Chunnuan, Huang Jinsha, Zhang Guoxin, Xu Xiaoyun, Shen Yan, Lin Zhicheng, Wang Tao
Abstract excerpt
BACKGROUND: Accumulating evidence has demonstrated that the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a part of Lewy body inclusions and involves the pathogenesis of Parkinson's disease (PD). However, it remains unknown whether or not genetic variation at the GAPDH locus contributes to the risk for PD. METHODS: A total of 302 sporadic PD patients and 377 control subjects were recruited in our study for...
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