Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Target Identification of Compounds from a Cell Viability Phenotypic Screen Using a Bead/Lysate-Based Affinity Capture Platform.

Journal of biomolecular screening - 1 Feb 2016

Tang Hua, Duggan Shannon, Richardson Paul L, Marin Violeta, Warder Scott E, McLoughlin Shaun M

Abstract excerpt

The pharmaceutical industry has been continually challenged by dwindling target diversity. To obviate this trend, phenotypic screens have been adopted, complementing target-centric screening approaches. Phenotypic screens identify drug leads using clinically relevant and translatable mechanisms, remaining agnostic to targets. While target anonymity is advantageous early in the drug discovery process, it poses...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Survival
Share to Drug Discovery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Evaluation, Preclinical

Share to Drug Industry

Share to Pharmaceutical Preparations

Share to Phenotype

Source

Identifiers

PMID: 26676096
DOI: 10.1177/1087057115622431

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Target Identification of Compounds from a Cell Viability Phenotypic Screen Using a Bead/Lysate-Based Affinity Capture Platform.PMID 26676096Read ↗

High-content phenotypic and pathway profiling to advance drug discovery in diseases of unmet need.Semantic proximity Read ↗

Affinity purification in target identification: the specificity challenge.Semantic proximity Read ↗

From Phenotypic Hit to Chemical Probe: Chemical Biology Approaches to Elucidate Small Molecule Action in Complex Biological Systems.Semantic proximity Read ↗

Design of phenotypic screens for bioactive chemicals and identification of their targets by genetic and proteomic approaches.Semantic proximity Read ↗

Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling, and Sensitive Detection of a Cancer Biomarker.Semantic proximity Read ↗

Phenotypic screening: A more rapid route to target deconvolution.Semantic proximity Read ↗

Hit Triage and Validation in Phenotypic Screening: Considerations and Strategies.Semantic proximity Read ↗

Identification of protein binding partners of small molecules using label-free methods.Semantic proximity Read ↗

Enrichment analysis for discovering biological associations in phenotypic screens.Semantic proximity Read ↗

Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses.Semantic proximity Read ↗

Chemo‐proteomics in antimalarial target identification and engagementSemantic proximity Read ↗

Aggregated Compound Biological Signatures Facilitate Phenotypic Drug Discovery and Target Elucidation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.