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Article

Enrichment analysis for discovering biological associations in phenotypic screens.

Journal of chemical information and modeling - 24 Feb 2014

Polyakov Valery R, Moorcroft Neil D, Drawid Amar

Abstract excerpt

A phenotypic screen (PS) is used to identify compounds causing a desired phenotype in a complex biological system where mechanisms and targets are largely unknown. Deconvoluting the mechanism of action of actives and identification of relevant targets and pathways remains a formidable challenge. Current methods fail to use the rich information available regarding compounds and their targets in a systematic way...

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PMID: 24437550
DOI: 10.1021/ci400245c

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