Article
From Phenotypic Hit to Chemical Probe: Chemical Biology Approaches to Elucidate Small Molecule Action in Complex Biological Systems.
Molecules (Basel, Switzerland) - 3 Dec 2020
Pasquer Quentin T L, Tsakoumagkos Ioannis A, Hoogendoorn Sascha
Abstract excerpt
Biologically active small molecules have a central role in drug development, and as chemical probes and tool compounds to perturb and elucidate biological processes. Small molecules can be rationally designed for a given target, or a library of molecules can be screened against a target or phenotype of interest. Especially in the case of phenotypic screening approaches, a major challenge is to translate the...
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