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Article

Local genotype influences DNA methylation at two asthma-associated regions, 5q31 and 17q21, in a founder effect population.

Journal of medical genetics - 1 Apr 2016

Al Tuwaijri Abeer, Gagné-Ouellet Valérie, Madore Anne-Marie, Laprise Catherine, Naumova Anna K

Abstract excerpt

BACKGROUND: Two asthma-associated regions 17q12-q21 and 5q31.1 harbour genes that show strong effect of genotype on expression levels. DNA methylation has an important role in gene regulation; therefore, we examined DNA methylation at promoters of 12 genes from 5q31 and 17q12-q21 regions. Our goal was to determine whether DNA methylation was associated with predisposition to asthma and whether such a relationship...

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Source

Identifiers

PMID: 26671913
DOI: 10.1136/jmedgenet-2015-103313

Genes

ZPBP2
GSDMA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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