Article
African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans.
Genome medicine - 29 Sept 2022
Washington Charles, Dapas Matthew, Biddanda Arjun, Magnaye Kevin M, Aneas Ivy, Helling Britney A, Szczesny Brooke, Boorgula Meher Preethi, Taub Margaret A, Kenny Eimear, Mathias Rasika A, Barnes Kathleen C, Khurana Hershey Gurjit K, Kercsmar Carolyn M, Gereige Jessica D, Makhija Melanie, Gruchalla Rebecca S, Gill Michelle A, Liu Andrew H, Rastogi Deepa, Busse William, Gergen Peter J, Visness Cynthia M, Gold Diane R, Hartert Tina, Johnson Christine C, Lemanske Robert F, Martinez Fernando D, Miller Rachel L, Ownby Dennis, Seroogy Christine M, Wright Anne L, Zoratti Edward M, Bacharier Leonard B, Kattan Meyer, O'Connor George T, Wood Robert A, Nobrega Marcelo A, Altman Matthew C, Jackson Daniel J, Gern James E, McKennan Christopher G, Ober Carole
Abstract excerpt
BACKGROUND: Asthma is the most common chronic disease in children, occurring at higher frequencies and with more severe disease in children with African ancestry. METHODS: We tested for association with haplotypes at the most replicated and significant childhood-onset asthma locus at 17q12-q21 and asthma in European American and African American children. Following this, we used whole-genome sequencing data from...
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