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Article

Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes.

American journal of physiology. Endocrinology and metabolism - 1 Mar 2016

Bitsi Stavroula, Ali Houda, Maskell Lauren, Ounzain Samir, Mohamed-Ali Vidya, Budhram-Mahadeo Vishwanie S

Abstract excerpt

The POU4F2/Brn-3b transcription factor has been identified as a potentially novel regulator of key metabolic processes. Loss of this protein in Brn-3b knockout (KO) mice causes profound hyperglycemia and insulin resistance (IR), normally associated with type 2 diabetes (T2D), whereas Brn-3b is reduced in tissues taken from obese mice fed on high-fat diets (HFD), which also develop hyperglycemia and IR....

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Identifiers

PMID: 26670484
DOI: 10.1152/ajpendo.00211.2015
PMCID: PMC4773651

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Source receipt: pubmed, retrieved 7 Sept 2026.

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