Article
Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation.
Communications biology - 28 Aug 2020
Mostafa Dina, Yanagiya Akiko, Georgiadou Eleni, Wu Yibo, Stylianides Theodoros, Rutter Guy A, Suzuki Toru, Yamamoto Tadashi
Abstract excerpt
Pancreatic β-cells are responsible for production and secretion of insulin in response to increasing blood glucose levels. Defects in β-cell function lead to hyperglycemia and diabetes mellitus. Here, we show that CNOT3, a CCR4-NOT deadenylase complex subunit, is dysregulated in islets in diabetic db/db mice, and that it is essential for murine β cell maturation and identity. Mice with β cell-specific Cnot3...
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