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Article

Characterization of Nob3, a major quantitative trait locus for obesity and hyperglycemia on mouse chromosome 1.

Physiological genomics - 9 Jul 2009

Vogel Heike, Nestler Matthias, Rüschendorf Franz, Block Marcel-Dominique, Tischer Sina, Kluge Reinhart, Schürmann Annette, Joost Hans-Georg, Scherneck Stephan

Abstract excerpt

New Zealand obese (NZO) mice present a metabolic syndrome of obesity, insulin resistance, and diabetes. To identify chromosomal segments associated with these traits, we intercrossed NZO mice with the lean and diabetes-resistant C57BL/6J (B6) strain. Obesity and hyperglycemia in the (NZO x B6)F2 intercross population were predominantly due to a broad quantitative trait locus (QTL) on chromosome 1 (Nob3; logarithm...

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Identifiers

PMID: 19470805
DOI: 10.1152/physiolgenomics.00011.2009
PMCID: PMC2712221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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