Article

Can Stemness and Chemoresistance be Therapeutically Targeted via Signaling Pathways in Ovarian Cancer?

2018-06-15

Abstract excerpt

Ovarian cancer is the most lethal gynecological malignancy. Poor overall survival, particularly for patients with high grade serous (HGS) ovarian cancer, are often attributed to late stage at diagnosis and relapse following chemotherapy. HGS ovarian cancer is a heterogenous disease in that few genes are consistently mutated between patients. Additionally, HGS ovarian cancer is characterized by high genomic instabi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ff0a165f-1e1a-585d-a76d-e0594da959d9
DOI: 10.20944/preprints201806.0262.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Can Stemness and Chemoresistance be Therapeutically Targeted via Signaling Pathways in Ovarian Cancer?DOI 10.20944/preprints201806.0262.v1Read

Investigating Molecular Profiles of Ovarian Cancer: An Update on Cancer Stem CellsSemantic proximity Read

Characterization of stem cell and cancer stem cell populations in ovary and ovarian tumorsSemantic proximity Read

Epithelial ovarian cancer stem cells: underlying complexity of a simple paradigmSemantic proximity Read

Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance.Semantic proximity Read

Understanding and targeting cancer stem cells: therapeutic implications and challengesSemantic proximity Read

Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancerSemantic proximity Read

Ovarian cancer cells with the CD117 phenotype are highly tumorigenic and are related to chemotherapy outcome.Semantic proximity Read

Cancer Stem Cells in Ovarian Cancer—A Source of Tumor Success and a Challenging Target for Novel TherapiesSemantic proximity Read

Ovarian cancer stem cells: still an elusive entity?Semantic proximity Read

Ovarian cancer stem cell: A potential therapeutic target for overcoming multidrug resistanceSemantic proximity Read

A comprehensive overview of ovarian cancer stem cells: correlation with high recurrence rate, underlying mechanisms, and therapeutic opportunitiesSemantic proximity Read

The hitchhikers guide to cancer stem cell theory: Markers, pathways and therapySemantic proximity Read