Article
Characterization of primary ovarian cancer cells in different culture systems.
Oncology reports - 1 May 2010
Liu Te, Cheng Weiwei, Lai Dongmei, Huang Yong, Guo Lihe
Abstract excerpt
The concept of cancer stem cells (CSCs) provides a new paradigm for understanding cancer biology. Here we report how culture conditions affect the characteristics of primary ovarian cancer cells. Cancer cells disaggregated from ovarian serous adenocarcinoma and maintained in serum-free system culture formed sphere cells that exhibited several properties expected for CSCs. These include self-renewal,...
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