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Article

Crucial role of HMGA1 in the self-renewal and drug resistance of ovarian cancer stem cells

26 Aug 2016

Abstract excerpt

Cancer stem cells are a subpopulation of cancer cells characterized by self-renewal ability, tumorigenesis and drug resistance. The aim of this study was to investigate the role of HMGA1, a chromatin remodeling factor abundantly expressed in many different cancers, in the regulation of cancer stem cells in ovarian cancer. Spheroid-forming cancer stem cells were isolated from A2780, SKOV3 and PA1 ovarian cancer...

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PMID: 27561949
DOI: 10.1038/emm.2016.73

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