Article
Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS.
Journal of neuroinflammation - 16 Dec 2015
Schrewe L, Lill C M, Liu T, Salmen A, Gerdes L A, Guillot-Noel L, Akkad D A, Blaschke P, Graetz C, Hoffjan S, Kroner A, Demir S, Böhme A, Rieckmann P, ElAli A, Hagemann N, Hermann D M, Cournu-Rebeix I, Zipp F, Kümpfel T, Buttmann M, Zettl U K, Fontaine B, Bertram L, Gold R, Chan A
Abstract excerpt
BACKGROUND: Despite pleiotropic immunomodulatory effects of apolipoprotein E (apoE) in vitro, its effects on the clinical course of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS) are still controversial. As sex hormones modify immunomodulatory apoE functions, they may explain contentious findings. This study aimed to investigate sex-specific effects of apoE on disease course of EAE...
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