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The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS Infection

15 Dec 2015

Abstract excerpt

Blood-stage Plasmodium chabaudi chabaudi AS infection requires cell- and Ab-mediated immunity to control acute and persistent infection, respectively. ICOS regulates CD4(+) T cell activation and promotes the induction of follicular Th (TFH) cells, CD4(+) T cells that support B cell affinity maturation within germinal centers (GCs), resulting in the production of high-affinity Abs. In this article, we demonstrate...

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PMID: 26667167
DOI: 10.4049/jimmunol.1403206

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Related research

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The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS InfectionPMID 26667167Read ↗

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Opposing Effects of ICOS on Graft-versus-Host Disease Mediated by CD4 and CD8 T CellsSemantic proximity Read ↗

Single-cell transcriptome profiling and the use of AID deficient mice reveal that B cell activation combined with antibody class switch recombination and somatic hypermutation do not benefit the control of experimental trypanosomosis.Semantic proximity Read ↗

B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection.Semantic proximity Read ↗

Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival.Semantic proximity Read ↗

Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiencySemantic proximity Read ↗

Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria.Semantic proximity Read ↗

A role for inducible costimulator protein in the CD28- independent mechanism of resistance to Toxoplasma gondii.Semantic proximity Read ↗

Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10.Semantic proximity Read ↗

Expression of cellular FLIP by B cells is required for their participation in an immune response.Semantic proximity Read ↗

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